Referenced in: none

Automatically associated channels: TRP , TRPA , TRPA1 , TRPV , TRPV1

Title: Contribution of TRPA1 as a downstream signal of proteinase-activated receptor-2 to pancreatic pain.

Authors: Yuka Terada, Mayuko Fujimura, Sachiyo Nishimura, Maho Tsubota, Fumiko Sekiguchi, Hiroyuki Nishikawa, Atsufumi Kawabata

Journal, date & volume: J. Pharmacol. Sci., 2013 , 123, 284-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24162021

Abstract
We examined if TRPA1, like TRPV1, contributes to pancreatic nociceptor excitation following proteinase-activated receptor-2 (PAR2) stimulation and to pancreatitis-related pain in mice. A PAR2-activating peptide, infused into the pancreatic duct, caused spinal Fos expression, which was prevented by AP18, a TRPA1 inhibitor. Repeated administration of cerulein caused referred hyperalgesia accompanying pancreatitis, which was reversed by SB366791, a TRPV1 inhibitor, but not AP18. AP18, administered in combination with a subeffective dose of SB366791, significantly suppressed the referred hyperalgesia. Our findings suggest that TRPA1, like TRPV1, mediates PAR2-triggered pancreatic nociception and that TRPA1 in collaboration with TRPV1 latently contributes to pancreatitis-related pain.