Referenced in: none

Automatically associated channels: Cav1.2

Title: CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population.

Authors: Kuanjun He, Zhiguo An, Qingzhong Wang, Tao Li, Zhiqiang Li, Jianhua Chen, Wenjin Li, Ti Wang, Jue Ji, Guoyin Feng, He Lin, Qizhong Yi, Yongyong Shi

Journal, date & volume: Br J Psychiatry, 2014 Jan , 204, 36-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24262814

Abstract
Common psychiatric disorders are highly heritable, indicating that genetic factors play an important role in their aetiology. The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.To investigate whether CACNA1C is a susceptibility gene for schizophrenia and major depressive disorder in the Han Chinese population.We carried out a case-control study of 1235 patients with schizophrenia, 1045 with major depressive disorder and 1235 healthy controls. A tag single nucleotide polymorphism (SNP) rs1006737 along with another 10 tag SNPs in the CACNA1C gene were genotyped in all samples.We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.