Referenced in: none

Automatically associated channels: TRP , TRPA , TRPA1

Title: Imaging agent of a TRPA1 inhibitor.

Authors: Jonas Malmquist, Alexandra Bernlind, Sandra Lindberg

Journal, date & volume: J Labelled Comp Radiopharm, 2013 Jul-Aug , 56, 536-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24285533

Abstract
A method for the preparation of [3'-(3) H]-4-(2'-chloro-6'-hydroxyphenyl)-2-thioxo-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-5(2H)-one (1), a TRPA1 inhibitor, was developed for the evaluation of imaging properties of a class of TRPA1 inhibitors. 1 was prepared via tritiation of a protected benzaldehyde followed by a tetrachlorosilane catalyzed multicomponent one-step fusion and was obtained at a specific activity of 0.9 TBq/mmol. A (3) H-NMR spectrum on 13.5 MBq at 75 μM was recorded.