Referenced in: none

Automatically associated channels: Kir6.2

Title: Polymorphisms in LEPR, PPARG and APM1 genes: associations with energy intake and metabolic traits in young children.

Authors: Marília Remuzzi Zandoná, Raquel Olmedo Rodrigues, Gabriela Albiero, Paula Dal Bó Campagnolo, Márcia Regina Vitolo, Silvana Almeida, Vanessa Suñé Mattevi

Journal, date & volume: Arq Bras Endocrinol Metabol, 2013 Nov , 57, 603-11

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24343628

Abstract
To assess the association of single nucleotide polymorphisms (SNPs) in five genes - leptin, leptin receptor (LEPR), adiponectin (APM1), peroxisome proliferator-activated receptor gamma (PPARG) and uncoupling protein 1 - with anthropometric, metabolic, and dietary parameters in a Southern Brazilian cohort of 325 children followed up from birth to 4 years old.SNPs were analyzed using polymerase chain reaction-based procedures, and their association with phenotypes was evaluated by t-test, analysis of variance, and general linear models.LEPR223Arg allele (rs1137101) was associated with higher daily energy intake at 4 years of age (P = 0.002; Pcorrected = 0.024). PPARG 12Ala-carriers (rs1801282) presented higher glucose levels than Pro/Pro homozygotes (P = 0.007; Pcorrected = 0.042).Two of the six studied SNPs presented consistent associations, showing that it is already possible to detect the influences of genetic variants on susceptibility to overweight in 4-year-old children.