Referenced in: none

Automatically associated channels: Kv10.1

Title: MLKL regulates necrotic plasma membrane permeabilization.

Authors: Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer

Journal, date & volume: Cell Res., 2014 Feb , 24, 139-40

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24418759

Abstract
Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma membrane and compromise its ability to preserve ionic homeostasis.