Referenced in: none

Automatically associated channels: Kir1.1 , Kir6.2

Title: Novel mutation c.597_598dup in exon 5 of ABCC8 gene causing congenital hyperinsulinism.

Authors: Radhika Jindal, Ayesha Ahmad, Mohammad Asim Siddiqui, Inderpal Singh Kochar, Subhash Kumar Wangnoo

Journal, date & volume: Diabetes Metab Syndr, 2014 Jan-Mar , 8, 45-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24661758

Abstract
Congenital hyperinsulinism (CHI), a clinically and genetically heterogeneous disease, characterized by the unregulated secretion of insulin from pancreatic β-cells, is the most common cause of persistent hypoglycemia in infancy. Early diagnosis and maintenance of normoglycaemia are essential to prevent adverse neurodevelopmental outcomes. The most common and severe forms of CHI are caused by inactivating mutations in ABCC8 and KCNJ11 genes, encoding the two subunits of the pancreatic β-cell ATP sensitive potassium channel (KATP). We report a case of neonatal CHI due to a novel homozygous recessive mutation in the ABCC8 gene.