Referenced in: none

Automatically associated channels: Cav2.2

Title: Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.

Authors: Michael P Winters, Nalin Subasinghe, Mark Wall, Edward Beck, Michael R Brandt, Michael F A Finley, Yi Liu, Mary Lou Lubin, Michael P Neeper, Ning Qin, Christopher M Flores, Zhihua Sui

Journal, date & volume: Bioorg. Med. Chem. Lett., 2014 May 1 , 24, 2053-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24726802

Abstract
A novel series of substituted tetrahydropyrrolo[3,4-c]pyrazoles were investigated as blockers of the N-type calcium channel (Cav2.2 channels), a chronic pain target.