Channelpedia

PubMed 24726803


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav2.2



Title: Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.

Authors: Michael P Winters, Nalin Subasinghe, Mark Wall, Edward Beck, Michael R Brandt, Michael F A Finley, Yi Liu, Mary Lou Lubin, Michael P Neeper, Ning Qin, Christopher M Flores, Zhihua Sui

Journal, date & volume: Bioorg. Med. Chem. Lett., 2014 May 1 , 24, 2057-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24726803


Abstract
A novel series of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles were investigated as N-type calcium channel blockers (Cav2.2 channels), a chronic pain target. One compound was active in vivo in the rat CFA pain model.