Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV4

Title: The TRPV4 channel.

Authors: Anna Garcia-Elias, Sanela Mrkonjic, Carole Jung, Carlos Pardo-Pastor, Rubén Vicente, Miguel A Valverde

Journal, date & volume: Handb Exp Pharmacol, 2014 , 222, 293-319

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24756711

Abstract
The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.