Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM6

Title: TRPM6.

Authors: Vladimir Chubanov, Thomas Gudermann

Journal, date & volume: Handb Exp Pharmacol, 2014 , 222, 503-20

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24756719

Abstract
TRPM6 is a bifunctional protein comprising a TRP cation channel segment covalently linked to an α-type serine/threonine protein kinase. TRPM6 is expressed in the intestinal and renal epithelial cells. Loss-of-function mutations in the human TRPM6 gene give rise to hypomagnesemia with secondary hypocalcemia (HSH), suggesting that the TRPM6 channel kinase plays a central role in systemic Mg(2+) homeostasis. In contrast, Trpm6 null mice show a delay in prenatal development, neural tube defects, and prenatal death. Possible functions of TRPM6 in prenatal and adult organisms will be discussed in this chapter.