PubMed 24773265

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPM3 , TRPP , TRPP2 , TRPV , TRPV1 , TRPV3

Title: The pharmacology of TRP channels.

Authors: Peter Holzer, Angelo A Izzo

Journal, date & volume: Br. J. Pharmacol., 2014 May , 171, 2469-73

PubMed link:

This themed issue of the British Journal of Pharmacology contains review and research articles on recent advances in transient receptor potential (TRP) channel pharmacology. The review articles, written by a panel of distinguished experts, address the rapid progress in TRP channel research in fields as diverse as oncology, urology, dermatology, migraine, inflammation and pain. These reviews are complemented by original research reports focusing, among others, on the emerging roles of TRPV1 in osteoporosis and cystitis and on evodiamine as a lead structure for the development of potent TRPV1 agonists/desensitizers. Other papers highlight the differences in TRPV3 pharmacology between recombinant and native systems, the mechanisms of TRPM3 activation/inhibition and TRPP2 as a target of naringenin, a dietary flavonoid with anticancer actions. New therapeutic opportunities in pain may arise from the strategy to combine TRP channel and cell membrane impermeant sodium channel blockers to inhibit sensory nerve activity.