Channelpedia

PubMed 24866018


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1



Title: Location is everything: let-7b microRNA and TLR7 signaling results in a painful TRP.

Authors: Clayton W Winkler, Katherine G Taylor, Karin E Peterson

Journal, date & volume: Sci Signal, 2014 , 7, pe14

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24866018


Abstract
Extracellular let-7b, a microRNA found in the central nervous system, affects neurons through its interaction with Toll-like receptor 7 (TLR7), but with divergent outcomes in different neurons. Lehmann et al. found that let-7b stimulation of cortical and hippocampal neurons led to neuronal apoptosis, whereas Park et al. report that let-7b activation of TLR7 stimulated the cation channel transient receptor potential A1 (TRPA1) on dorsal root ganglia sensory neurons and induced pain responses. The primary difference that may influence these distinct responses to let-7b is the localization of TLR7 to the endosome in the cortical and hippocampal neurons or the plasma membrane in the sensory neurons. These studies suggest that different types of neurons traffic TLR7 to distinct membrane locations, affecting the functional response of neurons to let-7b stimulation.