Referenced in: none

Automatically associated channels: Cav1.2

Title: CaV1.2 calcium channels: just cut out to be regulated?

Authors: Rachel D Groth, Natasha N Tirko, Richard W Tsien

Journal, date & volume: Neuron, 2014 Jun 4 , 82, 939-40

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24908477

Abstract
Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.