Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

Authors: Eric A Voight, Arthur R Gomtsyan, Jerome F Daanen, Richard J Perner, Robert G Schmidt, Erol K Bayburt, Stanley Didomenico, Heath A McDonald, Pamela S Puttfarcken, Jun Chen, Torben R Neelands, Bruce R Bianchi, Ping Han, Regina M Reilly, Pamela H Franklin, Jason A Segreti, Richard A Nelson, Zhi Su, Andrew J King, James S Polakowski, Scott J Baker, Donna M Gauvin, LaGeisha R Lewis, Joseph P Mikusa, Shailen K Joshi, Connie R Faltynek, Philip R Kym, Michael E Kort

Journal, date & volume: J. Med. Chem., 2014 Sep 11 , 57, 7412-24

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25100568

Abstract