Channelpedia

PubMed 25242356


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPV , TRPV1



Title: Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways.

Authors: Zhizheng Zhao, Huiting Fan, Tim Higgins, Jia Qi, Diana Haines, Anna Trivett, Joost J Oppenheim, Hou Wei, Jie Li, Hongsheng Lin, O M Zack Howard

Journal, date & volume: Cancer Lett., 2014 Dec 28 , 355, 232-41

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25242356


Abstract
Cancer pain is a deleterious consequence of tumor growth and related inflammation. Opioids and anti-inflammatory drugs provide first line treatment for cancer pain, but both are limited by side effects. Fufang Kushen injection (FKI) is GMP produced, traditional Chinese medicine used alone or with chemotherapy to reduce cancer-associated pain. FKI limited mouse sarcoma growth both in vivo and in vitro, in part, by reducing the phosphorylation of ERK and AKT kinases and BAD. FKI inhibited TRPV1 mediated capsaicin-induced ERK phosphorylation and reduced tumor-induced proinflammatory cytokine production. Thus, FKI limited cancer pain both directly by blocking TRPV1 signaling and indirectly by reducing tumor growth.