Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM7

Title: TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma.

Authors: Jian-Peng Chen, Jun Wang, Yi Luan, Cai-Xia Wang, Wen-Huan Li, Jin-Biao Zhang, Dan Sha, Rong Shen, Yan-Gang Cui, Zheng Zhang, Li-ming Zhang, Wei-Bo Wang

Journal, date & volume: Cancer Lett., 2015 Jan 28 , 356, 483-90

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25304381

Abstract
Our study observed the relationship between transient receptor potential melastatin 7 (TRPM7) expression and the metastatic process of nasopharyngeal carcinoma (NPC). We found that TRPM7 was overexpressed in 102 out of 206 (49.5%) human NPC cases and was significantly associated with clinical stage and lymphatic and distant metastasis. The results suggested that TRPM7 promotes NPC cell migration and invasion in vitro. Further, TRPM7 was correlated with poor clinical outcome and was an independent predictor for 5-year overall survival rate (HR, 1.832; 95% CI, 1.237-4.146 [P = 0.041]). In conclusion, TRPM7 promotes the metastasis of NPC and may serve as a prognostic marker in NPC patients.