Referenced in: none

Automatically associated channels: Kv10.1 , TRP , TRPV , TRPV1

Title: Spicing up the sensation of stretch: TRPV1 controls mechanosensitive Piezo channels.

Authors: Christophe Altier

Journal, date & volume: Sci Signal, 2015 , 8, fs3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25670201

Abstract
Piezo proteins--a family of mammalian cation-selective ion channels that respond to mechanical stretch--are molecular mediators of biological processes, including vascular tone, hearing, touch, and pain. In this issue of Science Signaling, Rohacs and colleagues demonstrate that activation of the heat-sensitive transient receptor potential vanilloid 1 (TRPV1), another cation channel, inhibits Piezo channels through a calcium-induced depletion of phosphoinositides. This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity.