Referenced in: none

Automatically associated channels: Slo1

Title: Regulation of Ca(2+) transient by PP2A in normal and failing heart.

Authors: Ming Lei, Xin Wang, Yunbo Ke, R John Solaro

Journal, date & volume: Front Physiol, 2015 , 6, 13

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25688213

Abstract
Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca(2+) handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.