Referenced in: none

Automatically associated channels: Kir1.1 , Kir6.2

Title: A novel mutation in ABCC8 gene in a newborn with congenital hyperinsulinism -a case report.

Authors: Nuran Uzunalic Üstün, Dilek Dilli, Ahmet Afsin Kundak, Nurullah Okumus, Derya Erdoğan, Sema Apaydın

Journal, date & volume: Fetal Pediatr Pathol, 2013 Dec , 32, 412-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23607867

Abstract
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy. The genetic basis of CHI includes a variety of defects in key genes regulating insulin secretion. Mutations in at least seven genes are found in 50% of cases. The most common forms of medically unresponsive CHI, which requires a near-total pancreatectomy are associated with autosomal recessive mutations in the ABCC8 and KCNJ11 genes encoding the two subunits of the pancreatic β-cell ATP-sensitive potassium channel. We report a neonate with CHI and have a novel homozygous splicing mutation in the ABCC8 gene.