Channelpedia

PubMed 23835478


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ2 , Kv7.2



Title: Channel gating pore: a new therapeutic target.

Authors: Polina Kornilov, Asher Peretz, Bernard Attali

Journal, date & volume: Cell Res., 2013 Sep , 23, 1067-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23835478


Abstract
Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.