Channelpedia

PubMed 24096830


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Nav1 , Nav1.4



Title: Effect of lamotrigine on Na(v)1.4 voltage-gated sodium channels.

Authors: Yoshihiko Nakatani, Haruka Masuko, Taku Amano

Journal, date & volume: J. Pharmacol. Sci., 2013 , 123, 203-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24096830


Abstract
Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na(+) current using HEK293 cells expressing mouse Nav1.4 VGSCs. By the treatment of LTG, Nav1.4 Na(+) current was inhibited in a dose-dependent manner. Moreover, 100 μM LTG decreased Nav1.4 Na(+) current around 40% and shifted the V1/2 of the inactivation curve to the hyperpolarization side by 20.96 mV. These findings suggest that LTG inhibits Nav1.4 Na(+) current and modifies the kinetics of the inactivated state.