PubMed 24371303

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ2 , Kv7.2

Title: KCNQ2 encephalopathy: delineation of the electroclinical phenotype and treatment response.

Authors: Adam L Numis, Marco Angriman, Joseph E Sullivan, Ann J Lewis, Pasquale Striano, Rima Nabbout, Maria R Cilio

Journal, date & volume: Neurology, 2014 Jan 28 , 82, 368-70

PubMed link:

Neonatal-onset epilepsies are rare conditions, mostly genetically determined, that can have a benign or severe phenotype.(1,2) There is recent recognition of de novo KCNQ2 mutations in patients with severe neonatal-onset epilepsy with intractable seizures and severe psychomotor impairment, termed KCNQ2 encephalopathy.(3,4) This is a rare condition and all patients reported so far were diagnosed well after the neonatal period.(3,4) We report on 3 new cases of KCNQ2 encephalopathy diagnosed in the neonatal period and studied with continuous video-EEG recording. We describe a distinct electroclinical phenotype and report on efficacy of antiepileptic drug (AED) therapies.