Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM1 , TRPM2

Title: TRPM2: a multifunctional ion channel for oxidative stress sensing.

Authors: Xiaochen Ru, Xiaoqiang Yao

Journal, date & volume: Sheng Li Xue Bao, 2014 Feb 25 , 66, 7-15

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24553864

Abstract
Transient receptor potential (TRP) superfamily is a superfamily of cation channels that can be divided into seven subfamilies. TRPM2 is the second member of the TRPM subfamily, which includes eight members, namely TRPM1-8. TRPM2 is widely expressed in excitable and non-excitable cells, where it forms a Ca(2+)-permeable cation channel and performs diverse cellular functions. TRPM2 channels are activated by ADP-ribose (ADPR), Ca(2+), H2O2 and other reactive oxygen species (ROS). It is established that TRPM2 serves as a cellular sensor for oxidative stress, mediating oxidative stress-induced [Ca(2+)]i increase and contributing to pathological processes in many cell types. Accumulating evidence has indicated that TRPM2 is a potential therapeutic target for oxidative stress-related diseases. This review will highlight recent progress in this field.