Channelpedia

PubMed 24756720


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPM6 , TRPM7



Title: TRPM7.

Authors: Andrea Fleig, Vladimir Chubanov

Journal, date & volume: Handb Exp Pharmacol, 2014 , 222, 521-46

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24756720


Abstract
The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain and an enzymatically active kinase domain. TRPM7 has been found in every mammalian tissue investigated to date. The two-in-one protein structure, the ubiquitous expression profile, and the protein's unique biophysical characteristics that enable divalent ion transport involve TRPM7 in a plethora of (patho)physiological processes. With its prominent role in cellular and systemic magnesium homeostasis, TRPM7 emerges as a key player in embryonic development, global ischemia, cardiovascular disease, and cancer.