Referenced in: none

Automatically associated channels: TRP , TRPA , TRPA1

Title: Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists.

Authors: Yun-Jin Hu, Miguel St-Onge, Sébastien Laliberté, Frédéric Vallée, Shujuan Jin, Leanne Bedard, Jean Labrecque, Jeffrey S Albert

Journal, date & volume: Bioorg. Med. Chem. Lett., 2014 Jul 15 , 24, 3199-203

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24835202

Abstract
A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.