PubMed 24880903

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1

Title: Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists.

Authors: Sébastien Laliberté, Frédéric Vallée, Pierre-André Fournier, Leanne Bedard, Jean Labrecque, Jeffrey S Albert

Journal, date & volume: Bioorg. Med. Chem. Lett., 2014 Jul 15 , 24, 3204-6

PubMed link:

We describe the discovery and advancement of a novel series of TRPA1 antagonist having an aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamide scaffold. The physical and in vitro DMPK profiles are discussed.