Channelpedia

PubMed 24961973


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: NOMPC , TRP , TRPA , TRPC , TRPC3 , TRPC6 , TRPM , TRPML , TRPML3 , TRPN , TRPV , TRPV4



Title: TRPs in Hearing.

Authors: Damiano Zanini, Martin C Göpfert

Journal, date & volume: Handb Exp Pharmacol, 2014 , 223, 899-916

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24961973


Abstract
Hearing is a particularly sensitive form of mechanosensation that relies on dedicated ion channels transducing sound-induced vibrations that hardly exceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears. In Drosophila, hearing has been shown to involve TRPA, TRPC, TRPN, and TRPV subfamily members, with candidate auditory transduction channels including NOMPC (=TRPN1) and the TRPVs Nan and Iav. In vertebrates, TRPs are unlikely to form auditory transduction channels, yet most TRPs are expressed in inner ear tissues, and mutations in TRPN1, TRPVA1, TRPML3, TRPV4, and TRPC3/TRPC6 have been implicated in inner ear function. Starting with a brief introduction of fly and vertebrate auditory anatomies and transduction mechanisms, this review summarizes our current understanding of the auditory roles of TRPs.