Referenced in: none

Automatically associated channels: TRP , TRPA , TRPA1 , TRPV , TRPV1 , TRPV3

Title: Pulchranins B and C, new acyclic guanidine alkaloids from the Far-Eastern marine sponge Monanchora pulchra.

Authors: Tatyana N Makarieva, Ekaterina K Ogurtsova, Yuliya V Korolkova, Yaroslav A Andreev, Irina V Mosharova, Ksenya M Tabakmakher, Alla G Guzii, Vladimir A Denisenko, Pavel S Dmitrenok, Hyi-Seung Lee, Eugene V Grishin, Valentin A Stonik

Journal, date & volume: Nat Prod Commun, 2013 Sep , 8, 1229-32

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24273853

Abstract
New marine natural products, pulchranins B and C (2 and 3), were isolated from the marine sponge Monanchora pulchra and their structures were established using NMR and MS analysis. Compounds 2 and 3 were moderately active as inhibitors of TRPV1 (EC50 value of 95 and 183 microM, respectively) and less potent against TRPV3 and TRPA1 receptors.