Referenced in: none

Automatically associated channels: Kir1.1 , Kir6.2

Title: A SNP in G6PC2 predicts insulin secretion in type 1 diabetes.

Authors: Srinath Sanda, Shan Wei, Tessa Rue, Heather Shilling, Carla Greenbaum

Journal, date & volume: Acta Diabetol, 2013 Jun , 50, 459-62

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22438186

Abstract
We investigated whether single nucleotide polymorphisms in genes related to glucose metabolism correlate with insulin secretion in type 1 diabetes patients. A cohort of 49 type 1 diabetes patients underwent serial mixed meal tolerance tests to assess insulin secretion. Patients were genotyped for SNPs related to glucose metabolism: CDKAL1 rs7754840, G6PC2 rs560887, HHEX rs1111875, KCNJ11 rs5215. Recently diagnosed patients (<100 days) homozygous for the G allele of G6PC2 had higher area under the curve C-peptide on mixed meal tolerance tests compared to non-homozygous patients (344.8 ± 203.2 vs. 167.9 ± 131.5, p = 0.04). Other SNPs did not correlate with insulin secretion in the new onset period. In a longitudinal survival analysis, homozygosity for the minor allele (A) in G6PC2 predicted more rapid loss of insulin secretion over time. A SNP in the beta cell gene G6PC2 may correlate with preserved insulin secretion in type 1 diabetes.