Referenced in: none

Automatically associated channels: Kir2.3

Title: Polymorphisms of the HTR3B gene are associated with post-surgery emesis in a Chinese Han population.

Authors: Xiao-Xu Ma, Qi-Xing Chen, Shui-Jing Wu, Yan Hu, Xiang-Ming Fang

Journal, date & volume: J Clin Pharm Ther, 2013 Apr , 38, 150-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23464988

Abstract
The serotoninergic receptor 5-hydroxytryptamine (serotonin) receptor 3 (HTR3) is instrumental in the regulation of nausea and emesis (vomiting).This study investigated whether common genomic variations of the A and B subunits of HTR3 (HTR3A, HTR3B) are associated with the incidence of post-operative vomiting in a Chinese Han population.Two hundred and thirty-one female Chinese Han patients undergoing gynaecological surgery with standardized general anaesthesia were recruited for the study. Clinical symptoms after surgery were recorded and direct DNA sequencing was performed to detect polymorphisms of HTR3A and HTR3B.Five single nucleotide polymorphisms (SNPs) in HTR3A and HTR3B were found, with R(2)  > 0·8 and minor allele frequency > 10%. One of these (rs3758987 in HTR3B) was statistically associated with vomiting, after adjusting for body weight, body mass index and duration of general anaesthesia in dominant and additive models (P = 0·047 and P = 0·034).The HTR3B rs3758987 SNP might serve as a predictor of post-operative vomiting in Chinese Han patients undergoing gynaecological laparoscopic surgery.