Referenced in: none

Automatically associated channels: Kv11.1

Title: Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Authors: Mark J Mitton-Fry, Steven J Brickner, Judith C Hamel, Lori Brennan, Jeffrey M Casavant, Michael Chen, Tao Chen, Xiaoyuan Ding, James Driscoll, Joel Hardink, Thuy Hoang, Erbing Hua, Michael D Huband, Meghan Maloney, Anthony Marfat, Sandra P McCurdy, Dale McLeod, Michael Plotkin, Usa Reilly, Shaughn Robinson, John Schafer, Richard M Shepard, James F Smith, Gregory G Stone, Chakrapani Subramanyam, Kwansik Yoon, Wei Yuan, Richard P Zaniewski, Christopher Zook

Journal, date & volume: Bioorg. Med. Chem. Lett., 2013 May 15 , 23, 2955-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23566517

Abstract
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.