Referenced in: none

Automatically associated channels: ClC4

Title: A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.

Authors: Beatriz Tavira, Juan Gómez, Francisco Ortega, Salvador Tranche, Carmen Díaz-Corte, Francisco Alvarez, Alberto Ortiz, Fernando Santos, María D Sánchez-Niño, Eliecer Coto

Journal, date & volume: Gene, 2013 Sep 25 , 527, 670-2

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23850580

Abstract
A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the Ka renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) <60 ml/min./1.73 m(2): age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p=0.03; OR=1.65, 95% CI=1.04-2.62). This novel finding could partly explain the reported greater risk of heart failure linked to the CLCNKA SNP, but requires confirmation on other populations.