Channelpedia

PubMed 23999312


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPV , TRPV4



Title: Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms.

Authors: M Skrzypski, M Kakkassery, S Mergler, C Grötzinger, N Khajavi, M Sassek, D Szczepankiewicz, B Wiedenmann, K W Nowak, M Z Strowski

Journal, date & volume: FEBS Lett., 2013 Oct 1 , 587, 3281-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23999312


Abstract
Transient receptor potential channel vanilloid type 4 (TRPV4) is a Ca(2+)- and Mg(2+)-permeable cation channel that influences oxidative metabolism and insulin sensitivity. The role of TRPV4 in pancreatic beta cells is largely unknown. Here, we characterize the role of TRPV4 in controlling intracellular Ca(2+) and insulin secretion in INS-1E beta cells. Osmotic, thermal or pharmacological activation of TRPV4 caused a rapid rise of intracellular Ca(2+) and enhanced glucose-stimulated insulin secretion. In the presence of the TRPV channel blocker ruthenium red (RuR) or after suppression of TRPV4 protein production, TRPV4 activators failed to increase [Ca(2+)]i and insulin secretion in INS-1E cells.