Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Gastrointestinal sensitivity and gastroesophageal reflux disease.

Authors: Annamaria Altomare, Michele Pier Luca Guarino, Sara Emerenziani, Michele Cicala, Asbjørn Mohr Drewes, Anne Lund Krarup, Christina Brock, Christian Lottrup, Jens Brøndum Frøkjaer, Rhonda F Souza, Gerardo Nardone, Debora Compare

Journal, date & volume: Ann. N. Y. Acad. Sci., 2013 Oct , 1300, 80-95

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24117636

Abstract
This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.