Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.

Authors: Jaime S Horton, Cadie L Buckley, Alexander J Stokes

Journal, date & volume: Channels (Austin), 2013 Jan 1 , 7, 17-22

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23221478

Abstract
Heart failure is becoming a global epidemic. It exerts a staggering toll on quality of life, and substantial medical and economic impact. In a pre-clinical model of cardiac hypertrophy and heart failure, we were able to overcome loss of heart function by administering the TRPV1 antagonist BCTC (4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide). The results presented here identify TRPV1 antagonists as new treatment options for cardiac hypertrophy and heart failure.