Referenced in: none

Automatically associated channels: TRP , TRPA

Title: Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier.

Authors: Katherine Baquerizo, Sadegh Amini, Jonette E Keri, Evangelos V Badiavas, George W Elgart

Journal, date & volume: J. Cutan. Pathol., 2013 Apr , 40, 413-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23379606

Abstract
We report the first documented case of an atypical form of transient reactive papulotranslucent acrokeratoderma (TRPA) in a patient heterozygous for the ΔF508 CFTR(cystic fibrosis transmembrane conductance regulator) mutation. TRPA represents a condition that classically presents with translucent to white plaques that become evident after water exposure. An atypical form with persistent lesions has also been described. Our patient is a 16-year-old girl with small, white papules coalescing into pebbly plaques on the palms. This condition is exacerbated after 5-10 min of water exposure and is associated with discomfort. The skin biopsy showed expanded stratum corneum, orthohyperkeratosis and dilation of eccrine ducts consisting with TRPA. A cystic fibrosis carrier state, barrier function defect, hyperhidrosis and the intake of cyclooxygenase inhibitors may have been pathogenic factors in our patient.