Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC3

Title: Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.

Authors: Shengjie Feng, Hongyu Li, Yilin Tai, Junbo Huang, Yujuan Su, Joel Abramowitz, Michael X Zhu, Lutz Birnbaumer, Yizheng Wang

Journal, date & volume: Proc. Natl. Acad. Sci. U.S.A., 2013 Jul 2 , 110, 11011-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23776229

Abstract
Mitochondrial Ca(2+) homeostasis is fundamental to regulation of mitochondrial membrane potential, ATP production, and cellular Ca(2+) homeostasis. It has been known for decades that isolated mitochondria can take up Ca(2+) from the extramitochondrial solution, but the molecular identity of the Ca(2+) channels involved in this action is largely unknown. Here, we show that a fraction of canonical transient receptor potential 3 (TRPC3) channels is localized to mitochondria, a significant fraction of mitochondrial Ca(2+) uptake that relies on extramitochondrial Ca(2+) concentration is TRPC3-dependent, and the up- and down-regulation of TRPC3 expression in the cell influences the mitochondrial membrane potential. Our findings suggest that TRPC3 channels contribute to mitochondrial Ca(2+) uptake. We anticipate our observations may provide insights into the mechanisms of mitochondrial Ca(2+) uptake and advance understanding of the physiological role of TRPC3.