Referenced in: none

Automatically associated channels: Kv1.5

Title: Channels: Sticking to nooks and crannies.

Authors: Heike Wulff, Vladimir Yarov-Yarovoy

Journal, date & volume: Nat. Chem. Biol., 2013 Aug , 9, 473-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23868316

Abstract
Drug design for voltage-gated ion channels has long been hampered by the absence of crystal structures and the challenge of achieving subtype selectivity. A combination of mutagenesis, electrophysiology and molecular modeling has led to the identification of a new side pocket binding site for the small molecule Psora-4 between the pore and the voltage-sensor domain of Kv1.5, offering opportunities to design allosteric ion channel modulators.