Referenced in: none

Automatically associated channels: TRP , TRPC

Title: [The role of calmodulin in calcium-dependent signalling in excitable cells].

Authors: Elzbieta Rebas, Tomasz Boczek, Antoni Kowalski, Kinga Kuśmirowska, Malwina Lisek, Ludmiła Zylińska

Journal, date & volume: Postepy Biochem., 2012 , 58, 393-402

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23662433

Abstract
Calmodulin (CaM) is a sensor protein, which takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. Calmodulin binds calcium ions during induction of intracellular signaling. It is also involved in silencing of calcium signal through activation of plasma membrane Ca(2+)-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels, e.g. voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors, calcium channels dependent on cyclic nucleotides or these located in endoplasmic reticulum (ryanodine receptors and all isoforms of IP3-dependent receptors).