Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV4

Title: Transient receptor potential vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?

Authors: J Fichna, A Mokrowiecka, A I Cygankiewicz, P K Zakrzewski, E Małecka-Panas, A Janecka, W M Krajewska, M A Storr

Journal, date & volume: Neurogastroenterol. Motil., 2012 Nov , 24, e557-60

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22882778

Abstract
Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro-inflammatory effects. In this study, we demonstrated for the first time that TRPV4 mRNA expression is up-regulated in patients with inflammatory bowel diseases (IBD). Furthermore, selective blockade of TRPV4 in the 2,4,6-trinitrobenzenesulfonic acid animal model alleviates colitis and pain associated with the intestinal inflammation. Our study indicates that TRPV4 may play a role in mechanisms of defense in intestinal inflammation and that TRPV4 may be an attractive target for future systemic or topic anti-inflammatory treatment in patients with IBD.