Channelpedia

PubMed 22884718


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ2 , KCNQ3 , Kv7.2 , Kv7.3



Title: KCNQ2 abnormality in BECTS: benign childhood epilepsy with centrotemporal spikes following benign neonatal seizures resulting from a mutation of KCNQ2.

Authors: Atsushi Ishii, Tasuku Miyajima, Hirokazu Kurahashi, Ji-wen Wang, Sawa Yasumoto, Sunao Kaneko, Shinichi Hirose

Journal, date & volume: Epilepsy Res., 2012 Nov , 102, 122-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22884718


Abstract
The molecular pathogenesis of benign childhood epilepsy with centrotemporal spikes (BECTS) remains unclear whereas mutations of the KCNQ2 and KCNQ3 genes have been identified as causes of benign familial neonatal convulsions. We report here a girl with benign neonatal convulsions followed by BECTS, for whom a mutation of KCNQ2 was identified. This case may provide the clue to the understanding of the molecular pathogenesis of BECTS.