Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM7

Title: The role of waixenicin A as transient receptor potential melastatin 7 blocker.

Authors: Byung J Kim, Joo H Nam, Young K Kwon, Insuk So, Seon J Kim

Journal, date & volume: Basic Clin. Pharmacol. Toxicol., 2013 Feb , 112, 83-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22901271

Abstract
Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca(2+) -activated Cl(-) conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer.