Channelpedia

PubMed 22905852


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPM2



Title: Selenium modulates oxidative stress-induced TRPM2 cation channel currents in transfected Chinese hamster ovary cells.

Authors: Mustafa Nazıroğlu, Cemil Ozgül, Mustafa Küçükayaz, Bilal Çiğ, Simon Hebeisen, Ramazan Bal

Journal, date & volume: Basic Clin. Pharmacol. Toxicol., 2013 Feb , 112, 96-102

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22905852


Abstract
It has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca(2+) levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H(2) O(2) ) are not well understood. We investigated the effects of selenium on H(2) O(2) -induced TRPM2 channel currents in the Chinese hamster ovary (CHO) cell line using patch-clamp and fura-2 fluorescence imaging techniques.