Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC6

Title: TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity.

Authors: Hongyu Li, Junbo Huang, Wanlu Du, Caixia Jia, Hailan Yao, Yizheng Wang

Journal, date & volume: J. Neurochem., 2012 Dec , 123, 1010-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23043486

Abstract
Excitotoxicity induced by NMDA receptor-mediated intracellular Ca(2+) ([Ca(2+) ](i)) overload is a major cause of delayed neuronal death in cerebral ischemia. Transient receptor potential canonical (TRPC) 6 protects neurons from ischemic brain damage. However, the mechanisms by which TRPC6 protects neurons are largely unknown. Here, we reported that TRPC6 suppressed the [Ca(2+)](i) elevation induced by NMDA and protected neurons from excitotoxicity. Over-expressing or down-regulating TRPC6 suppressed or aggravated Ca(2+) overload under excitotoxicity, respectively. TRPC6 protected cultured neurons from damage caused by NMDA toxicity or oxygen glucose deprivation (OGD). Moreover, the infarct volume in TRPC6 transgenic (Tg) mice was smaller than that in wild-type (WT) littermates. The TRPC6 Tg mice had better behavior performance and lower mortality than their WT littermates. Thus, TRPC6 inhibited NMDA receptor-triggered neurotoxicity and protected neurons from ischemic brain damage. Increase in TRPC6 activity could be a potential strategy for stroke prevention and therapy.