Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic β-cells.

Authors: Dominik P Waluk, Katarina Vielfort, Sepide Derakhshan, Helena Aro, Mary C Hunt

Journal, date & volume: Biochem. Biophys. Res. Commun., 2013 Jan 4 , 430, 54-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23159632

Abstract
Pancreatic β-cells secrete insulin in response to various stimuli to control blood glucose levels. This insulin release is the result of a complex interplay between signaling, membrane potential and intracellular calcium levels. Various nutritional and hormonal factors are involved in regulating this process. N-Acyl taurines are a group of fatty acids which are amidated (or conjugated) to taurine and little is known about their physiological functions. In this study, treatment of pancreatic β-cell lines (HIT-T15) and rat islet cell lines (INS-1) with N-acyl taurines (N-arachidonoyl taurine and N-oleoyl taurine), induced a high frequency of calcium oscillations in these cells. Treatment with N-arachidonoyl taurine and N-oleoyl taurine also resulted in a significant increase in insulin secretion from pancreatic β-cell lines as determined by insulin release assay and immunofluorescence (p<0.05). Our data also show that the transient receptor potential vanilloid 1 (TRPV1) channel is involved in insulin secretion in response to N-arachidonoyl taurine and N-oleoyl taurine treatment. However our data also suggest that receptors other than TRPV1 are involved in the insulin secretion response to treatment with N-oleoyl taurine.