Channelpedia

PubMed 23206861


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1 , TRPV , TRPV1



Title: Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

Authors: Giorgio Ortar, Luciano De Petrocellis, Aniello Schiano Moriello, Marco Allarà, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo

Journal, date & volume: Bioorg. Med. Chem. Lett., 2013 Jan 1 , 23, 138-42

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23206861


Abstract
A series of twenty-five derivatives of tetrahydro-β-carbolines 1-3 was synthesized and assayed on FAAH and TRPV1 and TRPA1 channels. Four carbamates, that is, 5a,c,e, and 9b inhibited FAAH with significant potency and interacted also effectively with TRPV1 and TRPA1 nociceptive receptors, while ureas 7b,d,f, and 8a,b were endowed with specific submicromolar TRPV1 modulating activities.