Channelpedia

PubMed 23415228


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Slo1 , TRP , TRPA , TRPA1



Title: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.

Authors: Rui Xiao, Bi Zhang, Yongming Dong, Jianke Gong, Tao Xu, Jianfeng Liu, X Z Shawn Xu

Journal, date & volume: Cell, 2013 Feb 14 , 152, 806-17

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23415228


Abstract
Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a general role of temperature reduction in lifespan extension. However, the underlying mechanisms remain unclear. One prominent model is that cold temperatures reduce the rate of chemical reactions, thereby slowing the rate of aging. This view suggests that cold-dependent lifespan extension is simply a passive thermodynamic process. Here, we challenge this view in C. elegans by showing that genetic programs actively promote longevity at cold temperatures. We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. Human TRPA1 can functionally substitute for worm TRPA-1 in promoting longevity. Our results reveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demonstrate that genetic programs contribute to lifespan extension at cold temperatures.