PubMed 23420534

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KChip2a , Kv1.5 , Kv4.2

Title: Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart.

Authors: Maoqing Tong, Eiichi Watanabe, Naoki Yamamoto, Misao Nagahata-Ishiguro, Koji Maemura, Norihiko Takeda, Ryozo Nagai, Yukio Ozaki

Journal, date & volume: Biol Rhythm Res, 2013 Aug , 44, 519-530

PubMed link:

Significant circadian variations exist in the frequency of cardiac arrhythmia, but few studies have examined the relation between cardiac ion channels genes and biological clocks. We investigated this relation using suprachiasmatic nuclei lesion (SCNX) and pharmacological autonomic nervous system block (ANSB) mice. Significant 24-h variations were observed in the expression of clock genes Per2, Bmal1, and Dbp and ion channel genes KCNA5, KCND2, KCHIP2, and KCNK3 in the control mice hearts. In the SCNX mice, all genes examined lost circadian rhythm. In the ANSB mice, the expressions of the three clock genes were dampened significantly but still had circadian rhythm, whereas the four ion channel gene expressions lost rhythm. Heart rate also lost circadian rhythm in both the SCNX and ANSB mice. These results suggest that some ion channel gene expressions might be regulated by the central clock in the SCN through the ANS but not the peripheral clock in the heart.