Referenced in: none

Automatically associated channels: TRP , TRPC , TRPC6

Title: Do cysteine residues regulate transient receptor potential canonical type 6 channel protein expression?

Authors: Florian Thilo, Ying Liu, Katharina Krueger, Nora Förste, Antje Wittstock, Alexandra Scholze, Martin Tepel

Journal, date & volume: Antioxid. Redox Signal., 2012 Mar 1 , 16, 452-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22004559

Abstract
The regulation of calcium influx through transient receptor potential canonical type 6 (TRPC6) channel is mandatory for the activity of human monocytes. We submit the first evidence that cysteine residues of homocysteine (HC) or acetylcysteine (ACC) affect TRPC6 expression in human monocytes. We observed that patients with chronic renal failure had significantly elevated HC levels and TRPC6 mRNA expression levels in monocytes compared with control subjects. We further observed that administration of HC or ACC significantly increased TRPC6 channel protein expression compared with control conditions. We, therefore, hypothesize that cysteine residues increase TRPC6 channel protein expression in humans.