Referenced in: none

Automatically associated channels: TRP , TRPA , TRPA1

Title: Receptor specificity defines algogenic properties of propofol and fospropofol.

Authors: Amol Patwardhan, Rebecca Edelmayer, Emil Annabi, Theodore Price, Phil Malan, Gregory Dussor

Journal, date & volume: Anesth. Analg., 2012 Oct , 115, 837-40

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22584560

Abstract
Propofol-evoked injection site pain is not observed with fospropofol. We hypothesized that unlike propofol, fospropofol does not activate the irritant receptor, transient receptor potential 1 (TRPA1).We tested the hypothesis using electrophysiology and behavioral studies.Our data demonstrate that propofol (100 μM) evokes an inward current only in TRPA1-expressing neurons. However, fospropofol (100 μM and 1 mM) is unable to evoke depolarizing currents in either TRPA1-positive or TRPA1-negative neurons. Both propofol and fospropofol produced general anesthesia.The lack of algogenic activity in fospropofol is most likely the result of its inability to activate TRPA1 on nociceptors.